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    歡迎訪(fǎng)問(wèn)中國科學(xué)院重慶綠色智能技術(shù)研究院!

    副研究員

    于永生
    性別:
    職稱(chēng):副研究員
    學(xué)歷:
    電話(huà):
    電子郵箱:yuyongsheng@cigit.ac.cn
    職務(wù):
    簡(jiǎn)歷

    于永生,20158月在香港中文大學(xué)獲博士學(xué)位,后繼續在香港中文大學(xué)從事博士后研究。20224月加入中科院重慶綠色智能技術(shù)研究院/中國科學(xué)院大學(xué)重慶學(xué)院。

    所屬部門(mén)

    抗耐性藥物研究中心

    研究領(lǐng)域

    多肽、蛋白化學(xué)生物學(xué);腫瘤靶向治療及機制研究。

    社會(huì )任職

     

    獲獎及榮譽(yù)

    2018 上海市浦江人才計劃

    代表論著(zhù)

    第一或通訊作者  

    1.Jiang HB, Li L, Zhu D, Zhou XY, Yu YS*, Zhou Q, Sun LM. A Review of Nanotechnology for Treating Dysfunctional Placenta. Frontiers in Bioengineering and Biotechnology. 2022, 10:845779.  

    2.Chen K, Liu MX, Wang F, Hu YP, Liu P, Li C, Du QQ, Yu YS*, Xiao XF, Feng Q. Highly Transparent, Self-Healing, and Self-Adhesive Double Network Hydrogel for Wearable Sensors. Frontiers in Bioengineering and Biotechnology. 2022, 10:846401.  

    3. Chen K, Hu YP, Wang F, Liu MX, Liu P, Li C, Yu YS*, Xiao XF, Feng Q. Ultra-stretchable, adhesive, and self-healing MXene/polyampholytes hydrogel as flexible and wearable epidermal sensors. COLLOID SURFACE A. 2022,645:128897.  

    4. Zhang KY, Wan Z, Jiang HB, Xiao XF, Feng Q, Meng YC, Yu YS*. Dimer targeting peptide mediated precise and controllable drug delivery by upconversion nanocarriers for breast cancer therapy. Materials and Design, 2021,203:109597.  

    5. Hou JJ, Tan YY, Su C, Wang T, Gao Z, Song D, Zhao J, Liao Y, Liu X, Jiang Y, Feng Q, Wan Z, Yu YS*. Inhibition of FAK enhances 5-FU chemosensitivity to gastric carcinoma via the MAPK-ERK and p53 signaling pathways. Computational and Structural Biotechnology Journal, 2020,18:125-136.  

    6.Huang Y, Feng Q, Jiang H, Zhou W, Chen J, Gao J, Wang K, Wan X, Yu YS*. Mimicking the Endometrial Cancer Tumor Microenvironment to Reprogram Tumor-Associated Macrophages in Disintegrable Supramolecular Gelatin Hydrogel. International Journal of Nanomedicine. 2020,15:4625-4637.  

    7.Jiang HB, Li L, Zhang J, Wan Z, Wang Y, Hou JJ, Yu YS*. MiR-101-3p and Syn-Cal14.1a Synergy in Suppressing EZH2-Induced Progression of Breast Cancer. OncoTargets and Therapy, 2020, 13:9599-9609.  

    8. Wan Z, Jiang HB, Li L, Zhu S, Hou JJ, Yu YS*. Carcinogenic roles and therapeutic effects of EZH2 in gynecological cancers. Bioorganic Medicinal Chemistry. 2020,28(7):115379.  

    9.Yu YS, Li SD, Wang K, Wan XP. A PDZ protein MDA-9/Syntenin: as a target for cancer therapy. Computational and Structural Biotechnology Journal, 2019, 17,136-141.  

    10. Liu JH, Qu JL, Zhou WD, Huang XJ, Xia J, Yu YS*. Syntenin-targeted peptide blocker inhibits progression of cancer cells. European Journal of Medicinal Chemistry, 2018,154:354-366.  

    11.Yu YS, Nie YY, Feng Q, et al.,Targeted covalent inhibition of Grb2?Sos1 interaction through proximity-induced conjugation in breast cancer cells. Molecular Pharmaceutics, 2017,14:1548-1557.  

    12.Yu YS, Xia J. Affinity-guided protein conjugationthe trilogy of covalent protein labeling, assembly and inhibition. Science China-Chemistry, 2016, 07:853-861.  

    13.Yu YS, Liu M, Ng TT, et al., PDZ-reactive peptide activates Ephrin-B reverse signaling and inhibits neuronal chemotaxis. ACS Chemical Biology, 2016, 11:149-158.  

    14.Yu YS, Wang JP, Liu JH, Ling DS, Xia J. Functional assembly of protein fragments induced by spatial confinement. PLoS One, 2015, 10:e0122101.  

    15.Gao J, Yu YS#, Zhang YY, et al., EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma, Biomaterials, 2012, 33: 270-82.  

    16.Gao J, Chen HW, Yu YS#, et al., Inhibition of hepatocellular carcinoma growth using immunoliposomes for codelivery of Adriamycin and ribonucleotide reductase M2 siRNA. Biomaterials, 2013, 34:10084-98.  

    17.Kang W, Ding CF, Zheng DN, Ma X, Yi L, Tong XY, Wu C, Xue C, Yu YS*, Zhou Q. Nanobody conjugates for targeted cancer therapy and imaging. Technology in Cancer Research & Treatment, 2021, DOI: 10.1177/15330338211010117.  

    18.Yang YY, Feng Q, Ding CF, Kang W, Xiao XF, Yu YS*, Zhou Q. Controllable Drug Delivery by Na+/K+ ATPase 1 Targeting Peptide Conjugated DSPE-PEG Nanocarriers for Breast Cancer. Technology in Cancer Research & Treatment, 2021, https://doi.org/10.1177/15330338211027898.  

    承擔科研項目情況

    2020 上海市科委港澳臺科技合作項目   主持負責人

    2019 國家自然科學(xué)基金青年項目        主持負責人  

    2018 上海市浦江人才計劃          主持負責人  

    2018 上海市衛健委科研項目           主持負責人  

    2018 中央高?;究蒲袠I(yè)務(wù)專(zhuān)項        主持負責人  

    2018 同濟大學(xué)優(yōu)秀青年人才培養行動(dòng)計劃   主持負責人